Caesarean section succeeded in the world's first "transplanted uterus" gave birth to a baby

In January 2014, it was reported that Swedish doctors successfully transplanted an embryo into a woman transplanted with a uterus. The woman is expected to become the first woman in the world to have a baby through a transplanted uterus.

Release date: 2014-10-09

The 36-year-old Swedish woman gave birth to a 1.8kg baby boy in Caesarean section in September this year. This is the first baby in the world to be born after the “transplantation of the uterus”. The mother and child are in good condition and have been discharged home.

The woman was diagnosed with MRKH syndrome (congenital without uterus and vagina), but her ovarian function was intact. The uterus she transplanted came from a 61-year-old family donor (menopausal 7 years ago), and the drug was used to suppress the immune system after transplantation to prevent rejection. At 32 weeks of babies, the woman had to stop her pregnancy due to pre-eclampsia and fetal heart rate, and gave birth to a baby boy by caesarean section. The child's father said: "Our baby is as healthy as other children, but his story is different!"

News background The world's first baby born through transplanted uterus is expected to be born

In January 2014, it was reported that Swedish doctors successfully transplanted an embryo into a woman transplanted with a uterus. The woman is expected to become the first woman in the world to have a baby through a transplanted uterus.

The woman underwent an open uterus transplant last year due to hereditary disease, the absence of the congenital uterus. The woman's womb comes from her mother. Therefore, this will also be the first case in the world where the fetus and mother are born from the same uterus. The egg of the woman's embryo comes from herself. This technology brings new hope to 200,000 infertile women in Europe.

“This is a valid proof of the treatment of uterine infertility.” The leader of the transplant team, Dr. MatsBrannstrom, from the Obstetrics and Gynecology, Sagergage College, Gothenburg, said. Dr. Brannstrom revealed that since September 2012 to April 2013, the team has performed 9 uterine transplants with success, with only minor complications. Of the recipients, 8 were congenital uterine vaginal absence (MRKH) syndrome, and 1 in 5,000 women suffered from this congenital disorder. The other one is a patient after cervical cancer hysterectomy.

Patients with MRKH syndrome have intact ovaries and can produce eggs, so they can receive IVF and "test tube" babies. A Norwegian MRKH syndrome patient said that her mother and sister are willing to donate the uterus. If the Swedish attempt is successful, "this means that I now have a chance to have my own child."

Dr. Brannstrom said that because the operation is still very new, it is not yet possible to determine success. "We know the pregnancy rate of the normal population - an embryo has a 25% chance, so we may need some trials before we get a successful pregnancy embryo, maybe we will be lucky."

However, psychologist StinaJ working with the Mats team? Rvholm expressed concern. He said: "The woman will have a big burden in the next few months. If all the trials work, she may be the first to succeed in giving birth to a child. It is also possible. It was the first time that all the trials were tried but eventually the children could not be born. This is the gap between hope and despair."

In 2000, a Saudi Arabian woman received a uterus transplant, but was subsequently removed again due to thrombosis. In 2011, a Turkish surgeon successfully completed a uterine transplant and successfully conceived, but eventually aborted.

Therefore, Dr. Brannstrom's team transplanted as many veins and arteries as possible around the uterus to improve blood supply to increase the chances of a successful pregnancy.

"It can be recorded in the history books that no one has done the first transplant in Saudi Arabia, nor is it a team that has done nine transplants in Sweden," Dr. Brannstrom said. "But who succeeded in the birth of the first baby after transplantation." ."

Source: China Obstetrics and Gynecology Network

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